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High-fat, greasy, and fried foods significantly worsen nausea and GI side effects on GLP-1 medications

It belongs to a new generation of incretin-based compounds often called triple agonists because of their ability to simultaneously activate three distinct metabolic receptors: the glucose-dependent insulinotropic polypeptide receptor (GIPR), the glucagon-like peptide-1 receptor (GLP-1R), and the glucagon receptor (GCGR)

The cardioprotective effects of mesenchymal stem cells, GLP-1RAs or pioglitazone may improve mitochondrial function via regulating autophagy and inflammatory signaling [87]

GLP-1 medicine for weight loss has previously only been available with an injection

however, the precise contribution of this pathway in humans is not yet fully characterised