Many patients also see improvements in blood pressure, cholesterol, and day-to-day energy
Deals with local companies have broadened distribution faster than Novos rollout of Wegovy in some markets
Finally, some clinical case studies and short series suggest their benefits also in patients with CKD stage 5D, although it should be recalled that this indication is not included in the labeling of arGLP-1 s.114,115 The Effect of semaglutide versus placebo on the progression of renal impairment in subjects with type 2 diabetes and chronic kidney disease (FLOW), a phase 3 clinical trial involving more than 3,000 patients with type 2 DM and moderate-severe CKD (eGFR 2575 ml/min/1.73 m2 and Urine Alb/Cr ratio of 3005,000 mg/g) is currently underway (NCT03819153)
We anticipate that this review will generate data that will help biomedical researchers or clinical workers develop obesity treatments based on GLP-1R agonists
While there is no official direct link between GLP-1 receptor agonists and specific electrolyte disorders, clinical experience and case reports have identified patterns of imbalance associated with the gastrointestinal effects of these medications
Ammar RA, Mohamed AF, Kamal MM, Safar MM, Abdelkader NF
