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Additionally, ICP6 can phosphorylate eIF2, a key initiation factor, thereby suppressing host protein synthesis and favoring production of viral proteins over cellular functions

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Furthermore these two reactions occur in the mitochondria, i.e., they also require Mg ++ chelated to ATP

Duburs, J

& Przybylkowski, A

A decrease in glutathione levels can lead to a decrease in methylation, which can have serious implications for cellular health and function