In neonates where intestinal barrier function is immature, proper availability of nutrients that contribute to the growth of IECs and maturation of the intestinal barrier is critical to support this protective effect
In our study, daily food intake was similar among cold-stressed mice, independent of genotype, suggesting that this magnitude of change from the TN to cold-stressed GLPDRKO mice was driven by factors beyond the volume of food introduced to the system
Ultimately, determining how elevated GSSG outside the ER leads to a more oxidizing ER lumen will require compartment-specific monitoring and manipulation of the glutathione redox state
Daniel Drucker (University of Toronto Lunenfeld-Tanenbaum Research Institute, Toronto, Canada)
NNMT consumes S-adenosylmethionine (SAM) and methylates nicotinamide, depleting cellular methyl pools and downstream NAD+ precursors
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