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5 L of each sample was analysed on a Acquity UPLC HSS-T3 column (50 2.1 mm, 1.8 m, Waters, MA, USA) by using gradient elution of 0.1% formic acid ( v / v ) in water as mobile phase A and 0.1% formic acid ( v / v ) in acetonitrile as mobile phase B, with a flow rate of 0.4 mL/min with the following gradient: 00.5 min (0% B), 0.8 min (15% B), 1.2 min (80% B), 1.4 min (80% B), 1.5 min (0% B), 2 min (0% B)

Still, many healthcare providers might not prescribe tirzepatide as a first-line treatment for Type 2 diabetes due to costs and available alternatives

Muscle-Strengthening Exercise Questionnaire (MSEQ): an assessment of concurrent validity and test-retest reliability

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Start at lower doses to assess tolerance and adjust based on results

NICE recommends annual uACR testing in people with diabetes