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J Biol Chem 295(13):42654276 Hirose Y, Onishi T, Miura S, Hatazawa Y, Kamei Y (2018) Vitamin D attenuates FOXO1-target atrophy gene expression in C2C12 muscle cells

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Antioxidant defence in recurrent abortion

Due to sperms abundance of membrane polyunsaturated fatty acids (PUFAs) and their own innate capacity to generate reactive oxygen species (ROS) (via abnormally shaped sperm morphology), human sperm are highly susceptible to oxidative stress (inflammation)

Furthermore, it decreases the mRNA and protein levels of Wnt1, Wnt3, TGF-1, Axin-2, fibronectin, COLIII, p-Smad3, -catenin, and the level and activity of cleaved caspase-3