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Outliers were removed from control data after identification with ROUT Q = 0.5% (number of outliers removed: NAD + /NADH ratio n = 2, NADP + /NADPH ratio n = 11 and GSH/SSG ratio n = 6, no outliers were identified for individual metabolites)

Sensor protein expression was induced with 0.2 mM IPTG and cells were cultivated for 16 h at 20 C

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An ALOX12-12-HETE-GPR31 Signaling axis Is a Key Mediator of Hepatic Ischemia-Reperfusion Injury