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The only reported change was seen was an increase in the motility rate of the isolated ileum of rabbits and increased muscle contractions in the isolated ileum of the guinea pigs

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This gave a reasonable fit for the OMZ data

Rather than pushing toward the maximum dose used in obesity trials, a clinician might: Start at a lower dose than usual Increase more slowly or pause increases for longer Stop escalating when acceptable appetite control and side-effect balance are reached, even if the dose is below the typical obesity dose This is where terms like microdosing guide and microdose guide show up online

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