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When both can be considered together In some cases, a combination protocol is appropriate

Although many such models describe the physicochemical attributes of P-gp interaction and are shown to have high predictability, existence of multiple binding sites and other complicating factors has prevented the development of a definitive SAR (Stouch and Gudmundsson 2002)

However, effects on advanced fibrosis remain under investigation, with phase 2 trials of semaglutide showing MASH resolution without confirmed fibrosis improvement