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Research Evidence: Studies, including a randomized controlled trial published in Clinical, Cosmetic and Investigational Dermatology, have shown that oral glutathione (500 mg daily) taken over 8-12 weeks can result in noticeable improvement in melasma severity compared to placebo

J Plant Physiol 168:20482055 Pasternak M, Lim B, Wirtz M, Hell R, Cobbett CS, Meyer AJ (2008) Restricting glutathione biosynthesis to the cytosol is sufficient for normal plant development