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Miscarriage rate According to the systematic reviews by Cochrane (100), AOX therapy of infertile men was not correlated with miscarriage rates mainly due to small number of studies addressing this parameter

P., Jr (2018)

All patients treated with opioids require careful and frequent reevaluation for signs of misuse, abuse, and addiction, because use of opioid analgesic products carries the risk of addiction even under appropriate medical use