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doi: 10.1371/JOURNAL.PMED.1004052 116 HardingJLOviedoSAAliMKOfotokunIGanderJCPatelSAet al
Since peptides, proteins, and hormones can directly reach the brain when administered intranasally via transport and diffusion along the olfactory and trigeminal nerves [241], future studies should explore whether intranasal melatonin could be a viable therapeutic option for increasing brain melatonin levels in individuals at risk of developing AD
Reperfusion occurring shortly after ischemia reduces infarct volume, but at a later period may exacerbate ischemic injury [10]
neutrophil extracellular traps induce endothelial cell activation and tissue factor production through interleukin-1 and cathepsin G
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