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Quick Answer: GLP-1 receptor agonists have not been definitively shown to directly cause clinically significant bone density loss, though the substantial weight reduction they produce may indirectly affect bone metabolism

10 Also, Bersani et al reported moderate-severe AEs in 3 fluoxetine-treated patients

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Studies have shown that oxidative stress and microvascular changes induced by diabetes can damage the integrity of the BTB in diabetic patients, leading to the infiltration of harmful substances into the seminiferous tubules, thereby affecting spermatogenesis [268]

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