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Patient reports of reduced hunger and changed food preferences became increasingly common as the medication gained wider use in endocrinology practices

This study investigated the potential association between GLP-1RAs and SSIBs by exploring the FDA Adverse Event Reporting System (FAERS) database

The sticker price of brand-name tirzepatide stops many patients in their tracks

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In the context of GLP-1R agonists, GLP-1-expressing NTS neurons project to the VTA [98], and administration of exendin-4 into this brain region reduces food intake [98,99,100] and the motivation to obtain a food reward [99, 100] without causing aversion [98,99,100]

Overall, the outcome is good, although it is quite unpredictable, with about 30% of patients have a recurrence