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Alongside this, they reduce glucagon output from alpha cells, which limits unnecessary glucose release from the liver and helps maintain steadier fasting and post-meal blood sugar levels throughout the day

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Lower GLP-1 equals increased appetite and weight gain

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(Lausanne) 11 , 178 (2020)

176,177 When GLP-1 binds to GLP-1R, it triggers the activation of G-proteins, leading to an increase in the intracellular second messenger cAMP