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Methylation Capacity Second, NNMT inhibition affects cellular methylation capacity: SAM is required for hundreds of methyltransferase reactions throughout the cell, and NNMT's consumption of SAM can deplete this critical resource, while the SAH produced by NNMT is a potent product inhibitor of many methyltransferases

In other words, assessment of pre-treatment SDMA had a poor sensitivity, but high specificity for predicting azotaemia following treatment of hyperthyroidism

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These data were correlated with clinical information and confirmed using a quantitative TMAO assay