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Weeks 13-16: The Optimization Phase (1.7 mg) For those who tolerate the medication well and need additional weight loss support, the dose may increase to 1.7 mg weekly

However, the use of a colistin-loading dose is hampered by the rather early onset of acute kidney injury (AKI)

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Semaglutide induces weight loss in subjects with type 2 diabetes regardless of baseline BMI or gastrointestinal adverse events in the SUSTAIN 1 to 5 trials