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Many trials report overall efficacy but lack adequate power or pre-specified plans to detect sex differences (Raparelli et al., 2020)

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This does not apply in any emergent or urgent situation

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A physician may need to evaluate persistent vomiting, severe abdominal pain, signs of dehydration, worsening reflux, gallbladder symptoms, low blood sugar risk in patients using diabetes medications, kidney function concerns, unintentional under-eating, rapid weakness or muscle loss, and medication interactions