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Key Takeaways: The FDA approved the first oral GLP-1 pill for weight loss (Wegovy pill, 25 mg) on December 22, 2025

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Lower calorie intake naturally leads to less energy availability, which can cause tiredness

While the drug is approved for type 2 diabetes management and cardiovascular risk reduction in high-risk patients with diabetes, it contains the same active ingredient (semaglutide) as Wegovy, but costs less than the injection

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Methods We performed a systematic literature search identifying articles reporting original data on GLP-1 and pain, including headaches