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Expected timeline: Month 1: 4 to 8 pounds lost, primarily appetite-driven deficit Month 2 to 3: 2 to 4 pounds per week sustained loss Month 4 to 6: Continued loss with improved body composition from muscle preservation Protocol 4: the over-40 male optimization stack Goal: Address age-related metabolic slowdown and body composition changes Stack: Tesamorelin: 2mg nightly before bed CJC-1295/ipamorelin: 100mcg/100mcg nightly (can be combined in same injection as tesamorelin) MOTS-c: 10mg weekly Why this works: After 40, GH decline accelerates and mitochondrial function degrades

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doi: 10.1007/s40268-019-0273-0 19 MatzaLSCurtisSEJordanJBAdetunjiOMartinSABoyeKS

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However, this is controversial and not fully conclusive