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Vitamin B12 functions as an essential cofactor for two enzymes central to this metabolic network

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Whereas the role of des-acyl (des-octanoyl) ghrelin in activating GHS-R1a is still debated, it has been suggested that des-acyl ghrelin can influence food intake by mechanisms independent of GHS-R1a (Toshinai et al., 2006) and by modulation of insulin sensitivity (Heppner et al., 2013)

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In policy circles, international networks such as C40 are increasingly acknowledging the role of cities in global consumption emissions and advocating for their reduction