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Irisin exerts neuroprotective effects on cultured neurons by regulating astrocytes

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Altern Med Rev 6:4509, PMID: 11703165 Jammes Y, Steinberg JG, Mambrini O, Brgeon F, Delliaux S (2005) Chronic fatigue syndrome: assessment of increased oxidative stress and altered muscle excitability in response to incremental exercise

However, the body's own production can be limited by illness, stress, taking medication or a disruption of the body's own synthesis and may no longer be sufficient to ensure optimal functioning of the body's own processes

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