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Furthermore, Isacson et al

From Phase 2 to Phase 3: how the story developed The Phase 2 NEJM study (Jastreboff 2023) The modern retatrutide story begins with Jastreboff AM et al., published in the New England Journal of Medicine in 2023 (DOI 10.1056/NEJMoa2301972)

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Manufacturers are addressing these concerns, for example, by producing new formulations with fewer side effects

I don't know if they're actually allowed to be prescribing, uh, caloric deficits in diets, but some things they're putting women on a thousand to 1200 calorie diets