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Results Twenty-three trials enrolling a total number of 181,143 participants were included

10.1161/CIRCRESAHA.123.324138 61 KleinF.DineshS.FiedlerD.GruenK.SchrepperA.BogovikuJ.et al (2024)

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However, covalent modification of the 20S proteasome by MG reduces its degradation activity, leading to persistent activation of the unfolded protein response (UPR), which ultimately triggers apoptosis and inflammatory responses (129, 130)