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Temperature-responsive hydrogels, typically based on poly(N-isopropylacrylamide) or chitosan-glycerophosphate systems, exploit local inflammatory heat or externally applied hyperthermia to achieve in situ gelation and controlled dissolution [200, 201]

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Other investigations using knock-out animal models have provided further evidence to indicate that GH influenced reproduction, but was not completely essential for generating offspring

Adapted from Stevenson et al.1 Radiation therapy appears to be less effective in LMM than in LM