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The conventionally accepted mechanism of action underlying the efficacy of DPP-4 inhibitors is that they improve glucose homeostasis through increased gut-derived plasma GLP-1 concentrations
7,8 Other drugs, such as vigabatrin (gamma-vinyl-GABA), an anticonvulsant used more frequently in pediatrics, dietary glycine deficiency from conditions, such as pregnancy, diabetes, malnutrition, and the use of antibiotics have also been reported as causes of glutathione deficiency
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