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This has even been termed the quarter fat-free mass rule. So, if GLP-1 interventions cause ~40% of weight loss as lean mass vs ~25% due to lifestyle, then GLP-1-based interventions are at least associated with disproportionate muscle mass loss

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This test revealed a near-significant protective effect of the GLP-1 RAs compared to DPP-4is with a slope of -0.0042 (p = 0.051)