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TBC1D9B was particularly interesting because of its putative function as a GTPase-activating protein (GAP) and its hypothesized role in endo-lysosomal trafficking, possibly by modulating the function of RAB proteins (i.e., RAB11A) 38 and/or related small GTPases

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As the field increasingly embraces combination therapies and network-level interventions, revisiting these systems with modern tools may yield treatments that address not only caloric intake but also the behavioral and psychological dimensions of metabolic disease

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