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Adding GIPR co-agonism (as in tirzepatide and retatrutide) introduces additional Gs signalling from a second receptor type expressed on adipocytes, beta cells, and hypothalamic neurones

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G., Snchez, E., Romero, I., Vidal-Puig, A., Berral, F

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In the same study, people using both the pill form and the injectable form of GLP-1s experienced frequent gastrointestinal adverse events

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