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Description

Abbreviations: AHI, Apnea Hypopnea Index

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Side effects usually involve gastrointestinal (GI) tract or digestive symptoms

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Preclinical research comes first, followed by Phase 1 safety trials, Phase 2 efficacy trials, Phase 3 registration trials, NDA submission, FDA review, and finally approval or rejection

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Hydration is also important because prolonged nausea accompanied by vomiting or diarrhea can contribute to volume depletion

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P = 0.0006), and dulaglutide in REWIND trial (HR 0.88

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