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Clinical trial data using body-composition analysis show that fat mass accounts for the majority of weight loss, while lean-mass changes reflect normal physiologic adaptation to reduced body weight and energy intake. Understanding this distinction is criticalbecause muscle wasting and expected lean-mass adaptation are not the same thing

The news around GLP-1s tends to read like a highlight reel

Diabetologia 54:26492659

Figure 17: Photograph of Professor Viktor Mutt (1923-1998) standing next to Sephadex column

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Holt MK, Richards JE, Cook DR, Brierley DI, Williams DL, Reimann F, et al