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Since the use of animal insulin for the treatment of diabetes in 1922, about nine major classes of drugs for the treatment of diabetes have been discovered and developed worldwide, including sulfonylureas, biguanides, -glucosidase inhibitors, insulins, thiazolidinediones (TZDs), meglitinides, GLP-1RAs, DPP-4 inhibitors, and SGLT-2 inhibitors

Bech, E

Gen Comp Endocrinol 175, 2733, doi: 10.1016/j.ygcen.2011.11.025 (2012)

Table of Contents: What distinguishes Semaglutide GLP-1 from Liraglutide

(Oxf.) 82 , 686694 (2015)

The one major obstacle to Black going down the histamine route was that its precise physiological role in acid secretion remained unclear