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Visible improvement often apparent by month 2-3 with continued gains through month 12 and beyond

Osei SP, Akomaning E, Florut TF, Sodhi M, Lacy BE, Aldhaleei WA, et al

Reconstituted solution is more vulnerable because hydrolysis, contamination risk, temperature swings, and repeated vial access all become more important

[1] In practice, 1 mL (which provides the full 100 mg of B and B, etc.) is a common dose for general supplementation in deficient states, but clinicians may start with lower volumes for mild deficiencies or in smaller patients

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Kumar V, Abbas AK, Fausto N, Mitchell R (2010) Basic Pathology 8 th China: Saunders, Elsevier