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CR also promotes expansion of bone-marrow adipose tissue (BMAT), which suppresses osteoblastogenesis

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It also downregulates key extracellular matrix regulators, resulting in improved liver function and histopathology

Seek urgent care for nausea, vomiting, abdominal pain, fast breathing, confusion, unusual fatigue, or fruity-smelling breath, especially during illness, fasting, surgery preparation, or major carbohydrate restriction

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For most patients this is clinically manageable the fat loss is greater and the absolute muscle loss is proportionally small relative to the significant health benefits of obesity treatment