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Leake, D

Rats with acute pancreatitis had a 21% reduction in cardiac output, a 37% decrease in contractility, a 23% decline in diastolic tension, and a twofold increase in the cardiac tissue edema index [80]

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found that epithalon can, when administered to both elderly monkeys and people, modulate the functional state of the pineal gland, which secretes melatonin to control the circadian cycle and wakefulness [8]

Interestingly, maternal caffeine intake, but not paternal caffeine intake, has been found to be associated with childhood obesity (Voerman et al., 2020)