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A 2025 orthopaedic sports medicine systematic review describes increasing use despite lack of FDA approval and bans in sport, and emphasizes that the evidence base is dominated by preclinical studies with limited high-quality human data

The status of Nrf2 is a key determinant of the effect of System X c GSH/GPX4 axis-targeted therapy in HCC, and therefore it is necessary to improve efficacy by inhibiting Nrf2 expression

10.1002/adhm.202100683 Summary Keywords system Xc -/GSH/GPX4 axis, ferroptosis, drug resistance, solid tumor, therapy Citation Li F-J, Long H-Z, Zhou Z-W, Luo H-Y, Xu S-G and Gao L-C (2022) System X c /GSH/GPX4 axis : An important antioxidant system for the ferroptosis in drug-resistant solid tumor therapy

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Nitric oxide: an endogenous modulator of leukocyte adhesion