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Drugs 32 , 355359 (2023)

Some start with microdosing to change their habits, while others stick with small doses long-term as part of a bigger health plan

GLP-1 analogs are water-soluble and large, which means they cannot diffuse easily

Others target specific conditions like gut inflammation or joint recovery that retatrutide does not directly address

The new label includes references to some of those postmarketing risks, including intestinal obstruction, [and] severe constipation including fecal impaction. Some patients who took Zepbound have filed lawsuits, accusing Eli Lilly of failing to properly warn them that Zepbound could increase their risk of severe gut problems, including bowel obstructions, pancreatitis, and gastroparesis

[1] [2] These medications work by mimicking the action of naturally occurring incretin hormones that the body produces in response to food intake