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These effects were associated with increased nuclear factor erythroid 2-related factor 2 (Nrf2) gene expression, suggesting involvement of both antioxidant and anti-inflammatory mechanisms (Jafari et al., 2022)

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We did not receive public comments on these proposals, and therefore, we are finalizing the eCQM certification requirements for eCQM reporting as proposed and to codify these requirements by adding new paragraph (h) Requirements for submission of electronic clinical quality measures (eCQMs) under the REHQR Program to 419.95

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However, there are no large-scale, long-term human safety trials