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Food and Drug Administrations Adverse Event Reporting System (FAERS) shows that liver-related side effects have been reported

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Published research describes suppression of NF-kappaB signaling, reduced production of pro-inflammatory cytokines (TNF-alpha, IL-1beta, IL-6), and modulation of the nitric oxide system (Catania et al., 2004)

This means you might be taking a high dose on paper, but your cells are only receiving a tiny fraction of it