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In trials for OSA (TRIUMPH1 and TRIUMPH2 OSA baskets), the primary endpoint is the change in the ApneaHypopnea Index (AHI) (number of apnea and hypopnea events per hour), and secondary endpoints include PatientReported Outcomes Measurement Information System SleepRelated Impairment (PROMISSRI), percentage of participants with a 50% decrease in AHI, and hypoxic burden as assessed by % change in Sleep ApneaSpecific Hypoxic Burden (SASHB)

Injection-site erythema and localized warmth are more pronounced at higher volumes

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Thiol-ene click chemistry has been shown to reproducibly form covalent thioether bonds between thiol and alkene-containing molecules

However, this method has been shown to be of limited clinical value since a considerable amount of guanine may originate from non-house-dust mite sources (Hallas et al., 1993)

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