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Rebound Hyperpigmentation (Darkening After Stopping) When steroids are discontinued, melanin production rebounds aggressively, causing: Dark patches Uneven skin tone Permanent pigmentation Many people restart the cream to fix thisleading to addiction-like dependency

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As exemplified in the successes of the FDA approved Adcetris and Kadcyla , this new therapeutic modality has huge potential for anti-cancer therapy and has attracted a great deal of attention from researchers and clinicians

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