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Impact of caloric restriction on health and survival in rhesus monkeys from the NIA study
[56] Additionally, by blockading FOXO transcription factors and NF-B, the drug modulates SASP and upregulates anti-apoptotic proteins (such as Bcl-2), potentially delaying tissue degeneration and offering anti-aging benefits
L., Lautrup S., et al
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Reversal of diet-induced obesity in mice The defining study, Neelakantan and colleagues in Biochemical Pharmacology (2018), reported that a potent methylquinolinium NNMT inhibitor reduced body weight, white-fat mass, adipocyte size and plasma cholesterol in diet-induced obese mice, without changing food intake or causing overt adverse findings [1]
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