Kidney function worsening is linked to parenteral-nutrition-dependent survival in palliative care patients
1,5,9 Protein isn't the only trigger, though
At 52 weeks, semaglutide-treated patients saw a mean improvement of 16.6 points in their scores on the Kansas City Cardiomyopathy Questionnaire (KCCQ), a validated measure of heart failure-related symptoms and physical limitations, compared with an 8.7-point improvement in the placebo group
If it is true rejuvenation there should be an increase in lifespan as well, and there is no mention of increased lifespan or whether that was even investigated
Caffeine tolerance can vary based on: Body weight Genetics Medications Health conditions Sleep quality Stress Food intake Regular caffeine use How quickly the drink is consumed A person who drinks coffee every day may respond very differently from someone who rarely consumes caffeine
It is clear that the CNS is necessary for GLP-1R mediated induction of visceral illness as mice with a CNS deletion of the GLP-1R develop conditioned taste aversion (CTA) to lithium chloride but not to liraglutide (Sisley et al., 2014)