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This review focuses on six commonly abused drugs (Table 1), classified based on their pharmacological and neurotoxic profiles: Psychostimulants: Methamphetamine (METH), cocaine and synthetic cathinones (bath salts) primarily act on monoaminergic systems, leading to disruptions in dopamine, serotonin, and norepinephrine signaling ( 2 O predominantly affect glutamatergic transmission by antagonizing NMDA receptors (NMDARs), causing excitotoxicity, mitochondrial dysfunction, and neuronal apoptosis
NACs ability to replenish glutathione and regulate brain glutamate levels can boost brain health
Description Overview BPC157 is a synthetic pentadecapeptide (15 amino acids) that comes from a fragment of a larger endogenous gastric protein complex commonly referred to as Body Protection Compound (BPC)
This review will provide new treatment ideas for a large number of OA patients, while avoiding the abuse of drugs and early artificial joint replacement surgeries
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