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IJDE 10 , 3744 (2025)

No contraindications (e.g., personal/family history of medullary thyroid carcinoma or MEN2, pregnancy)

The lack of a warning does not guarantee a drugs safety, effectiveness, or appropriateness for all patients or specific uses

Clin Drug Investig 40(8):695713

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Supporting this possibility, preclinical studies have reported that setmelanotide can effectively restore MC4R activity in obese animal models harboring LOF MC4R variants, thereby reducing food intake and increasing total energy expenditure, which results in significant weight loss