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These minor gene effects could be detected by studying a much larger sample size

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4 However, a 6-month placebo-controlled RCT in 54 non-smoking adults documented dose-dependent increases: at 1,000 mg/day, GSH levels rose 30-35% in erythrocytes, plasma, and lymphocytes, and 260% in buccal mucosal cells, with effects reversing after supplementation was stopped

Long-term data from tirzepatide trials extend to 72 weeks, showing continued weight loss with minimal plateauing

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