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Approximate pKa values for some organic acids CCl3CO2H CH3CO2H pyrH PhNH3 EtOH CH3CONH2 t-BuOH CH3COCH3 CH3SO2CH3 HC CH CH3CO2Et CH3CN CH3SOCH NH3 * 17 17 19 20 23 *25 *25 26 #4.7 NECCH2CO2Et Et3NH+ PhOH CH3NO2 EtSH MeCOCH2CO2Et EtO2CCH2CO2Et HOH cyclopentadiene 10 10 *35 *37 37 14 * 15 * 15 CH3CH-CH2 alkanes #40-44 Note: pyr-pyridine

Diabetologia 66 , 18691881 (2023)

Activation of these receptors in the brain leads to appetite suppression, which appears to be the primary mechanism of weight loss

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None of the offerings so far has been able to prevent muscle loss that frequently accompanies dramatic weight loss