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The mechanism of action involves several physiological effects: slowing gastric emptying (which prolongs the feeling of fullness after meals), reducing appetite through effects on brain centres that control hunger, and modulating glucose-dependent insulin secretion and suppressing glucagon in response to food intake

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Schandelmaier S, Briel M, Varadhan R et al (2020) Development of the Instrument to assess the Credibility of Effect Modification Analyses (ICEMAN) in randomized controlled trials and meta-analyses

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Particular emphasis was placed on the clinical relevance of these strategies and the central role of the Nutritionist in translating scientific evidence into practical, personalized care