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Further investigations of inherent variations of the GIPR within the normal population reveal that the missense GIPR variant, rs1800437 (Glu354Gln) that results in diminished GIPR signalling, leads to lower BMD and increased risk of non-vertebral fractures in perimenopausal Danish women

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Degeneration of mesencephalic dopaminergic neurons in klotho mouse related to vitamin D exposure

The understanding so far has been that GLP-1 analogues work by mimicking the action of a similarly shaped molecule called glucagon-like peptide, which is naturally released by the intestines soon after eating food