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Side Effects & Safety Per REDEFINE 1 and the Lau (2021) phase 2 program, trial-reported adverse events include: Nausea -- most common (25-40%)

Weight Loss Outcomes Associated With Sema Treatment for Patients With Overweight or Obesity

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Some patients may benefit from a gradual dose increase, while others simply need to improve protein intake, hydration, strength training, or sleep quality

Data Charting Relevant information from each included study was extracted using a data charting form that captured the following fields: author(s), year of publication, country of origin, whether the combination was an add-on or simultaneously used, study population characteristics relevant to the outcomes, and sample size, study design, intervention or exposition type and details of these, comparator, outcomes and their specifics, adverse effects reports, and key findings related to the scoping review questions

NOx was then assessed using a modified Griess reagent, and absorbance values were read at a wavelength of 540 nm